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HD3 Complication is the master of the watch industry 's Jorg Hysek, Valerie Ursenbacher, Replica Watches Fabrice Gonet co-founded a new watch brand. Jorg Hysek is the watch industry 's big-name designers , who played for Rolex, Vacheron Constantin , Breguet, Tiffany , Cartier and other world big, because of dissatisfaction with the shackles of the design, in order to realize their own ideas on the joint two founded HD3 brand. After two also watch industry genius . Uphold the original design and rare brand concept , HD3 's each series will be only limited production 33 , which also marked the trademark virtually let HD3 high price , HD3 watches prices mostly in the 250,000 -300 ten thousand yuan fingers, few tables below 20 million .

????HD3 contract fantasy set a lot of great brands, was founded by several gurus . Throughout the world the altar table , many of the world 's top watch brands are there one or several top genius creation , such as: Patek Philippe is created by " Anthony Baida " and " Jean Philippe " cooperation, Vacheron Constantin is by Jean -Marc Vacheron and Francois Constantin co- creation, Audemars Piguet (Audemars Piguet) is co- created by Jules-Louis Audemars and Edward-Auguste Piguet, Girard-Perregaux is co- created by Jean-Francois Bautte and Constant Girard, Jaeger-LeCoultre is Jacob . David co- created with Edmund yeah , there is now the limelight is busy Greubel Forsey brand was created by Robert Greubel and Stephen Forsey 's

???HD3 factory is located in Geneva, Switzerland, a vineyard , you can overlooking Lake Geneva , HD3 team is here already born: five works of different personalities and complex performance series Capture, Raptor, Idalgo, ThreeMinds and Vulcania. One HD3 Complication founder "Jorg Hysek" said: "The challenge is to go beyond the designer's ego, while changing forever do their best to break the limitations of http://www.buynewbox.com the only commercial restrictions breakthrough design and technology can be found from . a source of artistic inspiration . " ????Ideal Jorg Hysek is: "I want my watch to reflect the proportion of natural elements and the relationship between , is a bridge leading to the new century ." HD3 Complication watches design futuristic style , more technically challenging puzzle fear . Capture the Valerie Ursenbacher design , there Tourbillon Perpetual Calendar Tourbillon Perpetual Calendar and two styles. Jorg own design Idalgo XT-II design Swiss Replica Watches using double-sided disc , while points with a jump, fly back retrograde minutes , sweep seconds and a second time zone and date display . Raptor designed by the Fabrice Gonet , is a mechanical and quartz chronograph tourbillon watch dual display from the right side of the button to open the case . The outer layer is FG001 Tourbillon movement , was to show a large inner calendar , stopwatch and a second time zone. This year he also published Vulcania, both dual-axis tourbillon , roller -hour display and power reserve display , called one of the year's best watches . As another disc in three -dimensional space to display every minute of ThreeMinds, is jointly designed by the creative trio .

???Bovet ( Bovet ) is a brand people are rarely heard , but the Qing Emperor Daoguang it very well, including many nobles wear is Bovet ( Bovet ) watch, their favorite Li is a plus . Bovet ( Bovet ) table is very popular at the time of high society , the top Swiss watch brand Bovet (Bovet) with China has puzzled fate. Bovet in Switzerland remain small Replica Watches batch production mode manually . Bovet previously fixed annual production of 250 watches, today only 2000 annual watches , prices are expensive , low-end of the table basically in hundreds of thousands to hundreds of thousands , of high-end table up to 500 million yuan.

????1818 , Bovet brand founder Edouard Bovet as watchmaker Shortly after , he was sent to work in Guangzhou, China . Began to sell expensive high-end watches to Qing 's Western kings and nobles . As optimistic about Chinese people watch preferences and spending power , Edouard it was founded in 1822 in Guangdong Bovet brand , production lines are located in Switzerland. Products added to China 's popular elements , including francs, painting and other arts , very agreeable people like , Bovet and soon became a household name in Switzerland 's top brands.

??Bovet watches in a unique shape to reproduce the charm of old pocket watch by creation date, each watch is engraved , inlaid precious stones and enamel painting patterns and other processes Replica Watches produced exclusively by hand , so production is maintained at just more than a thousand pieces a year , more than 60 percent of which is the world's only this one . Because it is handmade , even with a watch also has differences, and therefore each piece is unique , and which includes a limited edition watch and Special Edition , absolutely precious, worthy of collection.

???A spokesman Roy Davidoff said large surface , thick leather or steel strap, thick body , such as a table ' masculine ' watch gas has no independence for men love , mechanical watches began to attract more and more sought after lady , so Bovet watch men and women did not have the equipment , suitable for all ears. Roy says , making a Bovet watch an average of four to six months time , if more complex production schedule Replica Watches more than a year , these tables use a lot of gold in the production process , but two-thirds of them in the production of gold when will be picked to go , so each table were priceless . ????Since Pascal Raffy When sowing president Wei , president of the ambitious expansion in succession , will broadcast Wittig promoted to a long history, while the strength of the watch brand . 2006 , Bovet founded in 1738 acquired a Swiss watch brand DIMIER, and STT STT Group's watchmaking movement factory , SPIR-IT silk factory tours and Aigat Stampers . And later acquired a factory in Geneva surface . Also holding Swiss Le Lieu of Aubert Complications watch company .

First, of course, Patek Philippe , the English abbreviation is PP. Undoubtedly the best brand is recognized around the world , known as " watch the blue blood aristocracy ." PP is not a complex movement known or gorgeous appearance , even in its men's shell little table inlaid any diamonds or precious stones, but it is always self-movement , limited Swiss Replica Watches online production , inherently has a restrained elegance noble . So , PP money can not wear those wearing yellow gold rings and a gold necklace , a sauna, and frequented karaoke OK " http://www.buynewbox.com replica watches landed gentry " does not deserve to have PP. The wearer should have a certain temperament and demeanor , elegant style of conversation , successful people have a " aristocratic " before they can be worn . PP and queen of the rings, bracelets and necklaces and other jewelry with " immunity " and put the stuff together PP always inconsistent, so when PP should avoid wearing then wear these tacky things. PP price in more than 100,000 yuan , as the entry-level 3919 also have about 110,000 .
Vitamina C para un buen funcionamiento de las neuronas
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La vitamina C, también conocida como ácido ascórbico, tendría un papel clave en el funcionamiento normal de las células de la retina y del sistema nervioso. Así lo revela un estudio publicado en The Journal of Neuroscience que fue realizado por un equipo internacional de científicos de la Argentina, de Chile y de EEUU.

 “La vitamina C es un antioxidante natural en las células del cerebro y de la retina. Si bien las propiedades de esta vitamina se han estudiado durante años, su papel en la neurotransmisión del sistema nervioso central era prácticamente desconocido”, afirmó la doctora Cecilia Calero, quien participó como becaria de doctorado en el estudio dirigido por el doctor Daniel Calvo, investigador del CONICET y director del Laboratorio de Neurobiología Celular y Molecular del Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI).
Mediante experimentos donde se analizó la función de los receptores del neurotransmisor GABA presentes en las neuronas de la retina y el cerebro, los investigadores demostraron que la vitamina C es un regulador crítico de la actividad de estos receptores.

“Los receptores de GABA son proteínas de la membrana celular que forman canales iónicos implicados en la transferencia de señales entre las neuronas. Podría decirse que su papel se asemeja al de los moderadores en una discusión”, explicó Calero.
Los científicos argentinos confirmaron que la vitamina C es un modulador de la actividad de los receptores de GABA. El trabajo fue realizado en colaboración con dos grupos del exterior, uno de ellos dirigido por el doctor Henrique von Gersdorff en la Universidad de Ciencias de la Salud de Oregon en EEUU y el otro por el doctor Luis Aguayo de la Universidad de Concepción en Chile.

“La retina fue elegida como uno de nuestros modelos de estudio, entre otras cosas, porque los dos protagonistas principales de nuestro trabajo, la vitamina C y los receptores de GABA, se encuentran altamente concentrados en esta área”, afirmó Calero.
La experta explicó que  “la activación de los receptores de GABA inhibe la comunicación entre las neuronas, es decir, actúa como un freno en la transferencia de señales entre estas células”. Y agregó: “Nuestros resultados mostraron que ésta vitamina era capaz de aumentar las respuestas inhibitorias del GABA en las células nerviosas. Esto controlaría la excitabilidad neuronal manteniéndola dentro de los niveles necesarios para su correcto funcionamiento. Este dato es esencial ya que cuando las neuronas se encuentran hiperactivas puede desarrollarse un fenómeno patológico denominado excitotoxicidad, mediante el cual las células son dañadas y destruidas.“

A la luz de los resultados publicados, Calero indicó: “Dado que la vitamina C se encuentra presente en altas concentraciones en la retina y en el cerebro, creemos que puede tratarse de un neuromodulador natural fundamental para el funcionamiento del sistema nervioso.”
Vitamina C y sistema nervioso central

La idea de utilizar a la vitamina C en el tratamiento o prevención de distintas patologías no es nueva, afirmó Calvo. Y continuó: “Varias de sus indicaciones generan controversias acerca de su efectividad, pero se la indica con frecuencia para reducir la duración de estados gripales y en la prevención de patologías cardiovasculares. El consumo diario controlado de vitamina C es extremadamente importante dado que los humanos no somos capaces de sintetizar esta vitamina. Esto significa que la única forma de incorporarla es a partir de la dieta. Si bien la importancia de la ingesta de vitamina C ha sido reconocida desde que se advirtió que era un agente fundamental para prevenir el escorbuto (siglo XV), habría que evaluar diversos aspectos clínico-farmacológicos antes de proponerla como una herramienta terapéutica para la prevención y tratamiento de patologías (retinianas como glaucoma o cerebrales como los ACV, depresión, Parkinson y Alzheimer). Evidentemente encontrar maneras de controlar de manera estricta los niveles de esta vitamina en la retina y el cerebro será un desafío futuro muy importante de la medicina. ”
Para el doctor Calvo, el conocimiento generado por el estudio publicado en The Journal of Neuroscience podrá ser evaluado por los profesionales de la salud en cuanto a su impacto en la medicina clínica.

El proyecto se financió en mayor medida por el Ministerio de Ciencia, Tecnología e Innovación Productiva a través de sus agencias -Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT) y el Fondo para la Investigación Científica y Tecnológica (FONCyT)- y el CONICET. Y parcialmente por los Institutos de Salud de los Estados Unidos (NIH, según sus siglas en inglés).

Fuente: Agencia CyTA – Instituto Leloir

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